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London: Global Science Books Ltd (2006) pp

Mouse small intestinal organoids are a revolutionary technology that simulates the structure of the real intestine in three-dimensional culture, providing a powerful platform that closely resembles the in vivo environment for disease research, drug screening, and developmental biology

They reduce the release of cytokines like IL-1, IL-6, and TNF, upregulate the anti-inflammatory cytokine TGF-, and downregulate the expression of disease-associated microglial (DAM) genes, ultimately enhancing A clearance [74]