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Similarly, Mn has also been utilized in the fabrication of TCPP-based MOFs to consume the intracellular GSH

All these properties have made glutathione a subject of interest for researchers

With consideration of oxidative and antioxidative defense, several antioxidant systems are involved in defending against ferroptosis

Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells

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