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5 Hypoxic stress at high altitude can trigger a series of physiological responses across multiple organ systems, especially the brain (increased cerebral blood flow), pulmonary system (increased ventilation and pulmonary vascular remodeling), cardiovascular system (increased heart rate, cardiac output, and systemic blood pressure), renal system (increased bicarbonate excretion and erythropoietin (EPO) secretion), and hematologic system (increased red cell mass, hemoglobin (Hb) concentration, and hematocrit (Hct)), thereby increasing oxygen content and delivery in the body

By reducing inflammation, fasting helps the body retain and even increase its supplies

10.1016/s0065-230x(08)60848-9 16 ClarkA

This creates more oxidative byproducts that glutathione helps neutralize

Finally, Kojic acid reduces the formation of excess melanin and lightens pigmentation