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Discussion Hypercoagulability leading to a thromboembolic event is a significant factor influencing the morbidity and mortality of -thalassemia patients

An important role of GSSG in the NFkB activating signal cascade is suggested by the fact that the potent NFkB inducer TPA increases intracellular GSSG levels and GSSG/GSH ratios

Mechanistically, we found that Ythdf2 deficiency not only suppressed the mRNA clearance of pluripotency-related genes (such as Nanog and Sox2 ), but also resulted in elevated expression of Gstp1 a glutathione S-transferase known for its role in detoxification and antioxidant defensewhich promotes PNT independently of its canonical detoxification functions (Semprasert et al

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