This centrally produced GLP-1 reaches specific receptors located in key structures involved in appetite regulation, such as the paraventricular nucleus, the lateral septum, the nucleus accumbens and the lateral parabrachial nucleus.2,3,6 Furthermore, it promotes aversive responses, inhibits neuroinflammation and gastric emptying, and stimulates sympathetic tone and thermogenesis in experimental models.2,4,6 Activation of GLP-1R on neurons in the arcuate nucleus stimulates the production of pro-opiomelanocortin (POMC), which in turn inhibits neurons that produce neuropeptide Y (NPY), thereby generating an appetite-suppressing response.2 GLP-1 production has also been reported in the olfactory bulb, although its significance remains unclear.2,6 GLP-1R has been identified in the sinoatrial node, atrial and ventricular myocytes, and vascular endothelium
Article 7 mins Value-Led Approaches to Reduce Healthcare Costs in the U.S
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinsons disease
A better question than Does it work? A lot of people ask, Do tanning injections work? That is the wrong first question
We've never had a single serious side effect at all in our program, but at this point, truly we hardly have people with nausea, GI upset