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Medications like semaglutide (Ozempic, Wegovy) are modified to resist DPP-4 breakdown, maintaining high GLP-1 activity for days rather than minutes
Consistent with these data, GLP-1 attenuated apoptosis of PC12 cells induced by carboxymethyl lysine via peroxisome proliferation activated receptor- (PPAR-) (194)
While these mechanisms improve glycaemic control, some patients experience gastrointestinal side effects that could potentially affect nutrient intake or absorption
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