Steps of the carnitine shuttle system Formation of Acyl-Carnitine: Long-chain fatty acids in the cytosol are activated to acyl-CoA, which then reacts with carnitine in the presence of CPT I to form acyl-carnitine
The architecture of these sites creates quasi-synaptic microdomains in which local concentrations can reach 10-100 M, thereby overcoming the low affinity (roughly K d approx 20-30 M) of the mitochondrial calcium uniporter (mtCU) (Eisner et al., 2013
As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) (Yang et al., 2022a)
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173 Technological progress should also emphasize the development of inherently interpretable model architectures, balancing performance with transparency to foster clinician trust