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Favorable reductions in ROS levels were restricted to the hippocampus, posterior cortex, and cerebellum, whereas other brain regions showed heterogeneous or unfavorable redox responses, including alterations in antioxidant enzyme activity

Alteration of KEAP1-NRF2 activity in ALS The human brain is an organ with elevated demand of energy, relying on oxidative metabolism and high consumption of O 2 to perform its functions [68]

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