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43 One RCT evaluated B12 alongside anti-depressants in patients with depression and moderately low B12 status (190300 ng/l) and found that 100% of those on B12, 1000 g per week i.m

2,3 Brain imaging has shown abnormalities in pain processing and reduced gray-matter volume in patients with fibromyalgia

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The length of time before you see the effects of vitamin B12 and symptoms subside, is going to depend on a few factors: B12 form Administration root Dosage Current vitamin B12 status Vitamin B12 is crucial for the production of blood cells, particularly red blood cells