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12, 25, 26 It has been also been claimed that GLP-1 may pass the bloodbrain barrier even outside these leaks, 26 but it is currently unknown to what extent this route may be involved in signaling from the gut to the brain
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The states with the highest prescribing rates are also among those with greater prevalence of diabetes and obesity, per CDC data, a rough indication that the medicines may be getting to areas where they are in greatest need while shortages, high price tags and insurance restrictions have limited their use
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