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For men, testosterone's anabolic effects on skeletal muscle create an environment in which MOTS-c's enhancement of glucose uptake and mitochondrial biogenesis may be particularly well expressed, making MOTS-c a natural companion to testosterone optimization programs

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It does not mean that one retatrutide molecule has been shown to bind all three receptors at the same time in one large receptor complex

Note on humans: These benefits are not established in humans no human dose-finding, efficacy, or safety studies of FOXO4-DRI have been completed [6]