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This question arises frequently as more patients begin glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) for type 2 diabetes and weight management

The peptide portion runs three residues end-to-end Glycine, Histidine, Lysine and binds a single Cu(II) ion at a chelation pocket formed by the histidine imidazole nitrogen, the glycine N-terminal amino group, and adjacent backbone amide nitrogens

DPP-4 inhibitors (DPP-4i) block degradation of GLP-1 and GIP, extend their insulinotropic effect, and improve glycemia [26]

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