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N Engl J Med 389(24):22212232 Vrints C, Andreotti F, Koskinas KC et al (2024) 2024 ESC guidelines for the management of chronic coronary syndromes: developed by the task force for the management of chronic coronary syndromes of the European Society of Cardiology (ESC) endorsed by the European Association for Cardio-Thoracic Surgery (EACTS)

Interestingly, in addition to proper supplementation support, another recommended treatment for cerebral folate deficiency is a dairy-free diet (something I advocate for in Hashimotos too), as mammalian milk is thought to contribute to folate receptor antibodies, and may block folate transport to the brain

This finding might suggest that regulation of mucus secretion by VIP is altered in COPD

Th1 cells promote the delayed cell-mediated immune response, but they can also stimulate B cells to produce antibodies when their ratio is appropriate

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