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I once received a bite across the top of my fingers that resulted in the rear fang penetrating skin across the top of a knuckle and that particular joint was achy and arthritic for a little over one week

Reason being, dihydroberberine is naturally made in the human digestive tract as a berberine metabolite -- it's produced when the gut microbiome hydrogenates berberine so that it can absorb it

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A randomised controlled intervention trial evaluating the efficacy of a Mediterranean dietary pattern on cognitive function and psychological wellbeing in healthy older adults: the MedLey study

Its essential that dose increases are done under medical supervision