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Some individuals report feeling overstimulated with high-dose supplementation, though these reports are anecdotal and not supported by controlled studies

(March 2021)

Advantage : CagriSema Safety and Tolerability# CagriSema : GI adverse events reported by 79.6% (vs 39.9% placebo) in REDEFINE 1, mostly transient and mild to moderate

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this does not establish efficacy or long-term safety