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The reduction in estrogen decreases natural oil production and collagen, making the skin thinner and more vulnerable to dryness and itchiness, says Karen Carlson, MD, an ob-gyn at the UNMC Medical Center in Omaha, Nebraska

If you're experiencing persistent or bothersome body aches, your provider may recommend a slower dose escalation, a switch to oral tirzepatide, orin some casesan alternative formulation like the Microdose GLP-1 Protocol ($129/mo flat) to allow your body more time to adapt

Eating enough protein is also important to preserve the muscle you have because losing muscle slows your metabolism

For oral semaglutide, start with 3 mg daily for 1 month, increase to 7 mg, then 14 mg after another month if necessary [4]

The GLP-1 component of Retatrutide has decades of safety data from medications like Ozempic