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Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)

A compound affecting so many biological pathways could easily have subtler harms that small trials (or enthusiastic investigators) might miss

this is not an overnight transformation, but the cumulative effect over several months is significant for many patients

In 2015, Chen et al

After treatment, the skin begins to remodel and rebuild collagen at a deep level over the course of the next several weeks