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This typically resolves within the first few days as the body adjusts

There is a growing demand for effective treatments that go beyond traditional insulin therapy, as sedentary lifestyles, unhealthy diets, and aging populations contribute to the increasing incidence of metabolic disorders worldwide

Vagal afferent neurons (VANs) expressing GLP-1Rs innervate intestinal mucosa and hepatic portal vasculature, suggesting these pathways may transduce peripheral GLP-1 RA effects to central satiety and glucoregulatory centers 57,58,59

Diarrhoea and abdominal pain , for instance, are cardinal symptoms of active Crohn's disease, and their worsening could indicate either a drug side effect or disease progression

Note: Some individuals may experience the skin temporary darkening before it gets lighter