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Binding of ligand leads to dimerization and autophosphorylation of a tyrosine kinase, which in turn leads to activation of the epidermal growth factor (EGF) intracellular signaling pathway 3

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Statistical significance between pairs of groups was assessed using an unpaired two-sided t-test, one-way ANOVA followed by the Dunnett multiple comparison test, or two-way ANOVA with the Tukey multiple comparison test, as indicated

However, emerging clinical observations and patient reports have prompted healthcare professionals to consider potential indirect effects on reproductive function

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