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Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis
The better the ingredient, the better and more predictable the outcome
As discussed before in this manuscript, BBB breakdown is considered to be the basic pathophysiology of HT, and BBBP is directly correlated with the appearance of subsequent HT, suggesting that the assessment of the BBB permeability should be the most promising predictor of HT (154)
However, whether the reduction of UA in the PD substantia nigra is causal, a consequence or an epiphenomenon related to other chemical processes in the PD brain remains unresolved
These studies contribute to a broader understanding of growth factor signaling and molecular regulation under controlled experimental conditions
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