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The Bottom Line: What You Need to Know Before Starting Retatrutide Let me synthesize everything into the critical realities you should understand before beginning treatment: Plan for indefinite use as your primary strategy

The mechanistic rationale for extrapolation, though, is reasonable

Most people reach a maintenance dose somewhere between 5 mg and 10 mg , though some require higher doses for continued weight loss

Additionally, Virta is the only program with peer-reviewed evidence of sustained weight loss outcomes for up to 12 months post GLP-1s, as demonstrated in a published study of diabetes members

Retatrutide produced 24.2% average weight loss in phase 2 trials