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TRIUMPH-2 (1,152 patients with obesity and type 2 diabetes) showed up to 20.8% weight loss and up to 1.6 percentage points of HbA1c reduction at the 12mg dose over 80 weeks
GlucoVantage dihydroberberine at 200mg serves as the flagship component
The precise timeline based on clinical trial tracking: Weeks 1-3: Mild symptoms beginning, most patients adapting to medication Weeks 4-8: Peak side effect period highest nausea, GI symptoms at their worst Weeks 9-12: Rapid improvement, most GI symptoms resolving Weeks 13-24: Minimal symptoms for most, discontinuation rate drops to under 2% Weeks 25-48: Essentially no side effects for 85%+, focus shifts to weight maintenance According to research published in the New England Journal of Medicine on GLP-1 agonists, this pattern is consistent across the entire class of incretin-based therapies
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Seek urgent medical attention if you develop significant hyperglycaemia with dehydration, or if you have symptoms that could suggest diabetic ketoacidosis (particularly if also taking an SGLT2 inhibitor)
