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Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice
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Long-Term Safety Its uncertain if retatrutide is safe in the long term since its still being researched
Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]
Finally, evaluation of small molecule GLP-1R agonists beyond their effectiveness in T2DM and obesity presents a significant area of opportunity
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