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It also supports the activity of other antioxidant enzymes and reactivates them

It acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD + to remove acetyl groups from proteins

This work was supported by R35HL139726 (ESN), R01HL156670 (CCS), K24HL150630 (CCS), and 5R01HL157973 (SF)

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