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2 Methods 2.1 Animals and procedures The animal experimental procedures were approved by the Animal Care and Use Committee of Oujiang Laboratory (SYXK2023-0047, OJLAB22121609), and were carried out in strict accordance with the National Institutes of Health Guidelines for the Use of Laboratory Animals

Accumulation of hemoglobin at the membrane surface and its auto-oxidation results in production of superoxide anion

It was first characterized as an incretin hormone, meaning it enhances glucose-stimulated insulin secretion from the pancreatic beta cells

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