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In one study of persons taking semaglutide, users regained up to two-thirds of the weight lost within six months of discontinuing the medication

However, nausea is the most commonly reported adverse effect, with incidence varying by medication and dose: approximately 15-30% for most GLP-1 agonists and up to 30-44% at higher doses of semaglutide and tirzepatide according to FDA prescribing information

Most patients begin experiencing weight loss within the first few weeks of treatment, with the most rapid reduction occurring between weeks 8-24 as the dose increases

One of the more important pathways is the inflammatory cascade: Metformin helps reduce inflammation, and the presence of inflammation is what triggers many of the negative downstream consequences of PCOS