Bioavailability is the key difference
As many as 24% of men and 29% of women reported taking a supplement (either a multivitamin that contains B12, a B-complex vitamin, or a standalone B12 supplement), according to the National Health and Nutrition Examination Survey (NHANES)
Established alternatives, such as lifestyle changes, hormone therapy, medications, and assisted reproduction, have better evidence and controlled application
To minimize TMAO production, it is vital to adhere to the divided dosing strategy, keeping single doses under 1,000 mg to ensure maximum small intestinal absorption and minimal spillover into the large intestine
They are not FDA-approved to diagnose, treat, cure, or prevent any disease