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The bottom line GLP-1 drugs are not a replacement for insulin, and they are not officially approved for T1D (outside of the new 2026 ADA recommendation for T1D with obesity)

How to Prevent Muscle Loss While Using GLP-1s This is one of the biggest concerns I hear from women: "Will I lose muscle on a GLP-1?" The short answer: you might, unless you're intentional

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Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]

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