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Secondary aims Secondary aims are to determine if, compared to placebo, treatment with 400 mg oral SAMe for 180 days will 1) maintain or improve performance as measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), 2) result in epigenetic changes in DNA methylation, and 3) be safe

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On-Treatment Monitoring IGF-1 should be rechecked at 8-12 weeks on sermorelin