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Pros : Effective for blood sugar control and significant weight loss Cons : Requires injections, and it may have side effects 6

Missing three consecutive days of injections during the loading phase can delay visible results by 1014 days because melanin synthesis requires sustained receptor activation

Once weekly or daily, as prescribedtiming depends on the drug

Pharma may invest in advocacy for anti-hunger/disease arguments

One potential option for streamlining enrollment and limiting screening failures is to apply a risk stratification approach, that uses data gleaned from studies investigating risk factors for the presence of NASH with fibrosis in the larger pool of patients with NAFLD (Fig