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Moving forward, Felson wrote, "it will be important to obtain data on whether semaglutide is similarly effective in persons with osteoarthritis without obesity, as well as better data on whether GLP-1 receptor agonists prevent progressive structural deterioration of the joint in osteoarthritis." This double-blind STEP-9 study was conducted at 61 sites across 11 countries starting in October 2021
N Engl J Med (2008) 359:157789
The in vitro findings suggest that increased fibrosis is not a result of calcineurin-induced hypertension
however, rosiglitazone was withdrawn from the European market in 2010 because of a high risk of myocardial infarction [56]
N.BurroughsH.GorchakovR.GunterS
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