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Zuckerman, J

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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

Chan JFW, Yuan SF, Kok KH, To KKW, Chu H, Yang J, Xing FF, Liu JL, Yip C, Poon R, Tsoi HW, Lo SKF, Chan KH, Poon VKM, Chan WM, Ip J, Cai JP, Cheng VCC, Chen HL, Hui CKM, Yuen KK