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This review synthesizes current understanding of the direct and indirect anti-inflammatory mechanisms of GLP-1s from both preclinical and clinical studies, outlining emerging concepts, clinical relevance, and the key questions that remain

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Abbreviations NAION: Nonarteritic anterior ischemic optic neuropathy RAPD: Relative afferent pupillary defect ODD: Optic disc drusen GLP-1 RA: Glucagon-like peptide-1 receptor agonist OCT: Optical coherence tomography ETDRS: Early Treatment Diabetic Retinopathy Study BMO: Bruchs membrane opening VA: Visual acuity IOP: Intraocular pressure GCA: Giant cell arteritis SAP: Standard automated perimetry MD: Mean deviation GCL: Ganglion cell layer EDI-OCT: Enhanced depth imaging optical coherence tomography VF: Visual field References Salvetat ML, Pellegrini F, Spadea L, Salati C, Zeppieri M

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