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Glutamine metabolism regulators associated with cancer development and the tumor microenvironment: A pan-cancer multi-omics analysis

The discovery that the G2019S mutation results in a constitutive two- to threefold increase in LRRK2 kinase activity [141, 142], along with evidence that LRRK2 mutations are risk factors for the more common sporadic form of PD [143, 144], prompted extensive investigation into its functional role

(PubMed) Ma F, Wu T, Zhao J, et al

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Whats more, the actors in the commercial all appear to be middle-aged, further narrowing the drugs target demographic