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Effective wound filling and infection prevention are crucial, especially in cases of irregularly shaped wounds 60,61

Glucocorticoids suppress endogenous GH secretion and simultaneously raise blood glucose

The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

Animal studies show no major adverse effects at therapeutic doses

Another strategy is target-modification