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They can degrade when exposed to heat, light, or enzymes, and they require protection to remain intact until they reach systemic circulation

1 Safety The most common adverse effect of semaglutide is an increase in heart rate, with an increase of 10 to 19 beats per minute in 41% of patients (34% with placebo) and 20 beats per minute in 26% of patients (vs

These included: Nausea the most frequently reported adverse effect, particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite These effects were generally mild to moderate in severity and tended to diminish over time

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