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The usual mechanistic explanation is that the GHRH arm drives somatotroph cAMP signalling while the GHRP arm additionally attenuates somatostatin tone, so the two are acting on different limbs of the same axis rather than competing for one receptor

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The drug may still offer important systemic benefits

As with other incretin-based agents, these events were generally more common than with placebo and were often dose-related , particularly during the dose-escalation phase of treatment

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