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By deeply integrating high-content zebrafish phenotypic data with multi-omics profiles (e.g., transcriptomics, proteomics, and metabolomics), and leveraging graph neural networks with multi-task learning algorithms, a virtual zebrafish efficacy prediction platform can be built (Figure 6B) ( in silico pre-screening of natural products, with top candidate compounds subsequently validated in human organoidzebrafish chimera models
Barriers such as needle anxiety or complex treatment regimens often prevent individuals from seeking care
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