semaglutide weight loss mechanism action Semaglutide and Tirzepatide - How

Glucagon-like peptide-1 (GLP-1) receptor agonists function like the incretin hormone GLP-1 that is released into the intestine after consumption of food

Although there were some initial concerns, increased rates of pancreatitis or pancreatic cancer have not been seen in meta-analysis

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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Those changes, however, did not translate into a delay of disease progression