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Coverage availability for Zepbound may also expand for some commercially insured patients later in 2026, as CVS Caremark has announced plans to restore Zepbound to its standard commercial formularies beginning in October

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PMID: 24818783 9

Factors Indicating Need for Dose Escalation Increase doses when minimal subjective improvements after 3-4 weeks at current dose, IGF-1 levels show minimal or no meaningful increase from baseline after an adequate trial period (e.g., 812 weeks), good tolerance without significant side effects suggesting room for higher dosing, and treatment goals require more aggressive approach than current dose provides