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The interaction profile shows limited hydrogen bonding and van der Waals forces, primarily involving residues ASP98, GLN64, LEU52, and TYR7
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( Gclc expression abolished the ability of FOS to restore diurnal variation in colonic inflammatory markers, including Tnf , Il6 , Ccl2 , and Nos2 , in obese mice ( Gclc knockdown significantly elevated colonic inflammatory marker levels, both overall and at each individual time point (Fig S13)
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