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It can decrease the fatty acid synthase (FSA) activity and increase -oxidation and carnitine palmitoyltransferase (CPT) activity in epididymal white adipose tissue (WAT

How will retatrutide perform in the remaining TRIUMPH trials

Any use of GLP-1 agonists for binge eating disorder is off-label and should involve specialist oversight with continued psychological support

Alternative GLP-1 formulations, dose adjustments, or additional supportive medications may improve tolerability whilst maintaining the metabolic benefits of therapy

As the medication's effects diminish, the underlying disease processes resume their natural course without pharmacological intervention, highlighting the importance of establishing alternative management strategies