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doi: 10.1677/jme.0.0100259 44 GallwitzBWittMPaetzoldGMorys-WortmannCZimmermannBEckartKet al

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However, the copper complex and hydrophilicity reduce actual dermal delivery without penetration enhancers like liposomes or DMSO

Clinical Relevance: Supports mechanism of centrally-mediated satiety enhancement rather than conditioned taste aversion