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Tirzepatide is a synthetic dual incretin receptor agonist (molecular mass 4.8 kDa, water-soluble) that has recently emerged as a novel therapeutic strategy for metabolic disorders by targeting both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors (GLP-1R), leading to marked improvements in glycemic control and body weight in clinical trials for T2DM [4] (Table 1, Figure 1)

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Neurology (1998) 10

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