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10.1111/apha.13067 53 SaffariS.KeyvanshokoohS.ZakeriM.JohariS
Nevertheless, comparative efficacy data remain inconclusive
Furthermore, dimerization of D2R with a GHSR1a mutant lacking constitutive activity still displayed dopamine-induced Ca 2+ mobilization, albeit considerably reduced, while two constitutively active mutants were absent in Ca 2+ mobilization, suggesting that Ca 2+ mobilization is independent of GHSR1a constitutive activity
Findings suggest this interaction may trigger signal cascades involving second messengers such as cAMP, leading to downstream transcriptional activity related to GH synthesis
In addition, hyperandrogenism by itself stimulates the deposition of adipose tissue in the visceral area, with further increase in insulin resistance, thus contributing to the vicious circle [17]
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