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PD cell model experiments confirmed that pathological S (e.g., 3K mutants or E46K) impairs vesicle trafficking and forms inclusion bodies by accelerating APT1-mediated depalmitoylation of microtubule-associated-protein-6 (MAP6) and impairing its ability to bind to vesicles
Biochem J 430:439451 Lewerenz J, Ates G, Methner A, Conrad M, Maher P (2018) Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system
In recent years, mass spectrometry-based quantification methodsboth label-based and label-freehave become essential tools in proteomics
New criteria say programs should stress abstinence
(PubMed) Hansen SN, Tveden-Nyborg P, Lykkesfeldt J
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