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People with MTHFR mutation have an increased risk of developing mental health issues, fatigue, cardiovascular problems, migraines, certain types of cancer, and neural tube defects in fetuses

5-Amino-1MQ is a first-in-class small molecule inhibitor designed to target Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that acts as a master regulator of the cellular "metabolic drain."