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The reason for the slow climb is simple: jumping straight to a high dose tends to cause more nausea and stomach upset
Slowed Metabolism: Muscle burns more calories than fat, so a decrease in muscle mass results in a lower resting metabolic rate, making weight management more challenging
Researchers are still studying long-term safety, weight maintenance, and rare risks in nondiabetic populations
Clin J Am Soc Nephrol 12:700710 Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Furtado RHM et al (2019) Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus: systematic review and meta-analysis of cardio
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