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Description

Haberland M, Montgomery RL, Olson EN

Osteoarthritis (OA) Osteoarthritis causes pain and stiffness due to both wear and tear and inflammation

Corticotropin-releasing hormone and the sympathoadrenal system are major mediators in the effects of peripherally administered exendin-4 on the hypothalamic-pituitary-adrenal axis of male rats

The FDA label advises monitoring renal function in patients experiencing severe GI adverse events and warns that AKI can occur

These concerns highlight the need for the development of novel GLP-1R agonists that minimize these side effects while maintaining beneficial metabolic outcomes