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[8] One such potential pathway involves the activation of phospholipase C (PLC), which researchers suggest may lead to the release of inositol triphosphate (IP3) and diacylglycerol (DAG)

191 EGCG has been shown to inhibit inflammatory enzyme activity in platelets 192 and suppress inflammatory signaling, inhibit expression of adhesion molecules, and promote expression of nuclear factor erythroid 2-related factor 2 (Nrf2, a protein that upregulates antioxidant pathways) in endothelial cells

[92] [93] Approval status [edit] Off-label uses [edit] In 2012, pharmaceutical company Abbott paid $1.6 billion in fines to US federal and state governments for illegal promotion of off-label uses for Depakote, including the sedation of elderly nursing home residents

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